Few people really want to work at night because the night is dark, lonely, and then there is, the time-lapse schedule is more risky for heart disease, diabetes, gastrointestinal problems and reproductive problems. If the human biological clock is misplaced for many years, the incidence of certain cancers will be relatively high.
This is bad news. Worse, the news is that no one really knows why dizziness is disturbed, and what effect sleep and wakefulness periods have on health. Although researchers are trying to analyze these issues, there are still many questions about circadian rhythms and biological clocks. But now, the paper in a new "Science" magazine provides some explanations. It may be a biological system involved, and perhaps a little warning of the night shift work.
Professor Laura Huber, professor of immunology at the University of Texas Southwestern Medical University, usually does not study circadian rhythms. Instead, her work focuses on how intestinal bacteria interact with the immune system. During the course of work, the lack of a protein known as NFIL3 was used to modulate the design of the mouse's immune cells. However, she realized that everything was not working well. Specifically, the walls of their gall bladders will loosen and begin to pull out from behind them, a condition known as rectal prolapse. What caused this to happen, Hooper's team found that mice also have helper T cells17 compared to healthy mice, which is not the expected result. When the elimination of NFIL3 their guts rate should be increased. Yu and his colleagues know that in normal mice, NFIL3 is controlled by the circadian clock: under the control of proteins in the body, the target sleep-wake cycle produces specific proteins, although the yield is relatively small. This in turn will determine the NFIL3 level. In this case, the absence of NFIL3 is the result of a genetic adjustment, and only then can it be known that this is sure to provoke a sleep-wake cycle in healthy mice and see what happens.
The researchers first turned on the lights in the squirrel cage for 6 hours earlier than in previous years. They believe that the cycle is 4 days, and then they turn on the lights for six hours, and still adjust the rats for four days. Then they repeat that the clock beats more than two times. RESULTS: When mice were exposed to this artificial time difference, their guts had more helper T cells17. This is a wise conclusion, they also have lower levels of NFIL3. But Hooper said: "The results are due to technical reasons, but we still can't explain this phenomenon." This is to admit the shortcomings in the study, but an additional, very telling result is at least partially compensated: the rats are also easier Development of colitis or colon inflammation compared with normal mice.
So what happened? Hooper, Yu, and their colleagues suggest that during the process of cell wandering around them, NFIL3 binds to the DNA when there is no restriction and encourages the production of helper T cells 17 . However, when NFIL3 promotes mutual implication, the production rate of T cells slows down, during this period, there may be many T cells that allow to be manufactured and closed later. NFIL3 surrounds mainly at night, when mice, which are small animals that come out of the night, they get up like normal. Therefore, the normal system, during the day, when rats slept, the circadian clock protein is at a higher level and T cells can be created. In the evening, when mice are active, clock protein levels drop and T cells are less.
"What's the reason for evolution?" asked Hooper. "I don't have solid science either. But my guess is that the T-helper cell's developmental control of the biological clock is a curious way to control how many cells you actually produce because they're all At the same time in the day, the greater significance of these preliminary observations is for further testing, especially for the experimental species of mice, which are known to mimic the development of inflammatory diseases in humans. This will allow those who are fully committed to work in the world. When he gets up, he goes to sleep, but if it eventually gets new treatments or therapies for the body's biological clock-related illness, it can at least make the night owls healthy.
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